Nanotechnology Project

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Environment, Health and Safety Research

Pulmonary Toxicity of Diesel Exhaust Particles

Project Information

Principal InvestigatorJane Ma
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialIncidental Nanomaterials
Impact SectorHuman Health
Broad Research Categories Hazard
NNI identifier

Funding Information

Anticipated Total Fundingn/a
Annual Fundingn/a
Funding SourceNIOSH
Funding MechanismIntramural
Funding SectorGovernment
Start Year2004
Anticipated End Year2004


The objective of this project is to characterize the role of generation of reactive oxygen species in pulmonary toxicity resulting from exposure to diesel exhaust particles. Specifically, the role of reactive oxygen species in the induction or degradation of pulmonary P450 enzymes and the resulting effects on xenobiotic metabolism and metabolic-dependent mutagenicity will be evaluated. Sources of reactive oxidant production in response to diesel exhaust particle exposure, such as reactive oxygen species production from P450 enzymes or nitric oxide production from nitric oxide synthase, will be characterized.