Nanotechnology Project

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Environment, Health and Safety Research

Pulmonary, Immune, and Dermal Effects of Welding Fumes

Project Information

Principal InvestigatorJames Antonini
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialIncidental Nanomaterials
Impact SectorHuman Health
Broad Research Categories Exposure
NNI identifier

Funding Information

Anticipated Total Fundingn/a
Annual Fundingn/a
Funding SourceNIOSH
Funding MechanismIntramural
Funding SectorGovernment
Start Year2002
Anticipated End Year2007


The goals of this project are to (1) design, construct, and test a generation system that would produce a consistent fume (concentration and characteristics) for inhalation exposure to rats; (2) characterize the welding fume as generated and within the inhalation chamber; (3) determine how characteristics change with distance from the generator source; (4) expose rats by inhalation to welding fume; (5) characterize pulmonary, immune, and dermal reactions to exposure; (6) determine the dose-response and time-course of these reactions; and (7) determine the effect of welding process (mild steel versus stainless steel) on pulmonary response.