Nanotechnology Project

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Environment, Health and Safety Research

Nanoparticles: Dosimetry and Risk Assessment

Project Information

Principal InvestigatorEileen Kuempel
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Hazard
Risk Assessment
NNI identifier

Funding Information

Anticipated Total Fundingn/a
Annual Fundingn/a
Funding SourceNIOSH
Funding MechanismIntramural
Funding SectorGovernment
Start Year2004
Anticipated End Year2009


In this project, a current rat lunch dosimetry model will be extended to include biologically relevant paths for the transport of nanoparticles to the blood and other organs as well as excretion. Data from the literature will be used to calibrate this model, and data from new studies at NIOSH and elsewhere will be used to validate the model. The model will be extrapolated to humans using human data where available (e.g., physiological parameters), and biologically based approaches to interspecies extrapolation will be applied to estimate from the rat model the parameter values not available in humans. These lung dosimetry models will be used in conjunction with rodent dose-response data to estimate risk of adverse health effects in workers and working lifetime exposure concentrations that are not expected to cause adverse health effects.