Nanotechnology Project

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Environment, Health and Safety Research

Recognition and Physicochemical Characterization of Nanomaterial-Peptide Interactions

Project Information

Principal InvestigatorJohn F Honek
InstitutionUniversity of Waterloo,
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Generation, Dispersion, Transformation etc.
NNI identifier

Funding Information

Anticipated Total Funding$86,883.00
Annual Funding$43,441.50
Funding SourceNSERC
Funding MechanismExtramural
Funding SectorGovernment
Start Year2005
Anticipated End Year2007


The interface between biological systems and nanomaterials is of critical importance to the understanding of how the properties of nanomaterials can be affected by their molecular interactions with biomolecules. This research is targeted to better understanding this type of interaction between peptide molecules (and potentially proteins) and leading nanomaterials such as carbon-based nanotube and fullerene-based materials. Research will focus on identifying sequences of peptides that have high-affinity for these materials. Isolation and study of these peptides with these materials will allow us to learn more about how biological systems interact with nanomaterials and what effects these interactions have on these materials at the molecular level as well as at the macroscopic level. For example, how is the solubility, aggregation, stability and other key physical chemical properties affected by these peptide interactions and can any changes in physical properties be correlated to these molecular level interactions.