Nanotechnology Project

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Environment, Health and Safety Research

Mechanisms of cellular interactions of functionalized rosette nanotubes

Project Information

Principal InvestigatorBaljit Singh
InstitutionUniversity of Saskatchewan
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Hazard
NNI identifier

Funding Information

Anticipated Total Funding$86,883.00
Annual Funding$43,441.50
Funding SourceNSERC
Funding MechanismExtramural
Funding SectorGovernment
Start Year2005
Anticipated End Year2007


Nanotechnology, the science of very small particles, is expected to alter the way we live our lives. Once realized, the potential of nanotechnology will enhance existing products and create new smart products. Before this all happens, many fundamental questions and issues need to be addressed. To develop a better relationship of nanotubes with the cells, it is critical to understand how cells interact with nanotubes. We have developed rosette nanotubes (RN), which are different than the commonly used single-walled carbon nanotubes. We propose to tag radioactively-labeled RN with a short peptide (RGD) conjugated to a fluorescent molecule. The RGD peptide plays important role in the function of defense cells such as neutrophils in our bodies. Therefore, we will examine how RGD-RN interact with the cells in vitro and in vivo. Because RGD interact with a ‘sticky’ protein called integrin beta-3, we will focus on the interactions between RGD-RN and the integrin. These studies will clarify fundamental processes of interaction of RN with the cells. Eventually, it is expected that we will find ways to use RN as smart weapons for precise delivery of drugs to treat diseases such as pneumonia.