Pulmonary Toxicity Screening Studies with Nano vs. Fine-Sized Particles in Rats.
|Principal Investigator||David B Warheit|
|Institution||DuPont Haskell Laboratory for Health and Environmental Sciences|
|Relevance to Implications||High|
|Class of Nanomaterial||Engineered Nanomaterials|
|Impact Sector||Human Health|
|Broad Research Categories||
|Anticipated Total Funding||n/a|
|Anticipated End Year|
In collaborative studies with Rice University, we have conducted in vivo pulmonary bioassay studies in rats comparing the pulmonary toxicity effects of both Nanoscale TiO2 dots (10 nm) and Nanoscale TiO2 rods ( 200 nm x 30 nm) vs. fine- sized TiO2 particles (300 nm) as well as assessing the toxicity of Nanoscale quartz particles vs. Min-U-Sil (fine-sized quartz particles). Our results indicate that particle size and surface area are not always the most important particle parameters in determining pulmonary toxicity, as the Nanoscale TiO2 particles were not more toxic than fine-sized TiO2 despite surface area differences of 4x and ~ 30x vs. fine-sized particle-types.