Nanotechnology Project

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Environment, Health and Safety Research

Neurotoxicity after Pulmonary Exposure to Welding Fumes Containing Manganese

Project Information

Principal InvestigatorJames Antonini
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialIncidental Nanomaterials
Impact SectorSafety
Broad Research Categories Hazard
Generation, Dispersion, Transformation etc.
NNI identifier

Funding Information

Anticipated Total Fundingn/a
Annual Fundingn/a
Funding SourceNIOSH
Funding MechanismIntramural
Funding SectorGovernment
Start Year2006
Anticipated End Year2010


Characterized the physical and chemical properties of generated welding aerosol. Compared the pulmonary, inflammatory, and immune responses after exposure to stainless steel and mild steel welding fumes. Designed and constructed a robotic welding fume generator and inhalation exposure system for laboratory animals. Initiated animal inhalation toxicity studies. Evaluated the translocation of welding fume metals from the lungs to other organ systems (e.g., central nervous system and cardiovascular system). Evaluated the potential neurotoxic effects in animals after inhalation of welding fume is being evaluated.