Neurotoxicity after Pulmonary Exposure to Welding Fumes Containing Manganese
|Principal Investigator||James Antonini|
|Institution||National Institute for Occupational Safety and Health|
|Relevance to Implications||High|
|Class of Nanomaterial||Incidental Nanomaterials|
|Broad Research Categories||
Generation, Dispersion, Transformation etc.
|Anticipated Total Funding||n/a|
|Anticipated End Year||2010|
Characterized the physical and chemical properties of generated welding aerosol. Compared the pulmonary, inflammatory, and immune responses after exposure to stainless steel and mild steel welding fumes. Designed and constructed a robotic welding fume generator and inhalation exposure system for laboratory animals. Initiated animal inhalation toxicity studies. Evaluated the translocation of welding fume metals from the lungs to other organ systems (e.g., central nervous system and cardiovascular system). Evaluated the potential neurotoxic effects in animals after inhalation of welding fume is being evaluated.