Nanotechnology Project

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Environment, Health and Safety Research

SUNANO - Risk assessment of free nanoparticles

Project Information

Principal InvestigatorHerman Autrup
InstitutionInstitute of Public Health and iNANO, University of Aarhus, Denmark
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Exposure
Risk Assessment
NNI identifier

Funding Information

Anticipated Total Funding$1,635,290.00
Annual Funding$545,096.67
Funding SourceThe Danish Strategic Research Council, Programme Commission on Nanoscience, Biotechnology and IT (NABIIT)
Funding Mechanism
Funding Sector
Start Year2007
Anticipated End Year2010


The objective of this project is to establish and validate toxicological test systems in order to perform an integrated hazard characterization of free nanoparticles of silver, ZrO2, SiO2 and TiO2 using a tiered approach. The toxicity of the particles will be assessed as a function of size, shape and dose (mass and surface area) in relevant human target cells and ecological indicator organisms. The potential toxicological mechanism of the particles will be investigated using a molecular toxicological approach, i.e. identify cellular response pathways, signalling pathway, genetic response and outcome, and the endpoints will in general be the same in human cells and the ecological test organisms. In order to establish dose-response relationships as a function of the particles variable, the particles will be extensively characterized at the different stages of the experimental studies.