Nanotechnology Project

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Environment, Health and Safety Research

Dermal Effects of Nanoparticles

Project Information

Principal InvestigatorAnna Shvedova
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Exposure
NNI identifierb4-9

Funding Information

Anticipated Total Funding$700,000.00
Annual Funding$233,333.33
Funding SourceNIOSH
Funding Mechanism
Funding Sector
Start Year2004
Anticipated End Year2007


Nanoparticles are new materials of emerging technological importance in different industries. Because dermal exposure is likely in a number of occupational settings, it is very important to assess whether nanoparticles could cause adverse effects to skin. The hypothesis is that nanoparticles are toxic to the skin and the toxicity is dependent on their penetration to skin, induction of oxidative stress, and content of transition metals. Because inflammation provides a redox environment in which transition metals can fully realize their pro-oxidant potential, a combination of inflammatory response with metal oxide particles, or iron-containing SWCNT will synergistically enhance damage to cells and tissue. Results obtained from these studies provide critical knowledge about mechanisms of dermal toxicity of nanoscale materials and will be used by regulatory agencies (OSHA and EPA) and industry to address strategies for assurance of healthful work practices and safe environments.

(Project budget is an estimate only, based on available data)