Nanotechnology Project

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Environment, Health and Safety Research

Systematic Microvascular Dysfunction Effects of Ultrafine Versus Fine Particles

Project Information

Principal InvestigatorVincent Castranova
InstitutionNational Institute for Occupational Safety and Health
Project URLView
Relevance to ImplicationsHigh
Class of NanomaterialEngineered Nanomaterials
Impact SectorHuman Health
Broad Research Categories Exposure
NNI identifierb5-37

Funding Information

Anticipated Total Funding$600,000.00
Annual Funding$200,000.00
Funding SourceNIOSH
Funding Mechanism
Funding Sector
Start Year2004
Anticipated End Year2007


Nanotechnology is one of the fastest growing emerging technologies in the United States and across the world. Defined as the manipulation of matter at near-atomic scales to produce new materials, structures, and devices with unique properties, nanotechnology has potential applications for integrated sensors, semiconductors, medical imaging, drug delivery systems, structural materials, sunscreens, cosmetics, and coatings. The NIOSH Nanotechnology Research Center identifies elucidation of cardiovascular effects of airborne nanoparticles as a critical issue. This study will compare the effects of inhalation exposure to fine vs. ultrafine TiO2 and monitor pulmonary effects and alterations in systemic microvascular function. The role of oxidant stress at the microvessels will be explored. Data will be disseminated by presentation at scientific meeting, publications in journals, summaries in the NIOSH e-News and Nanotech Web page, and meeting with partners.

(Project budget is an estimate only, based on available data)