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pH-sensitive enteric-coated particles

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As shown in the figure above a variety of different pharmaceutical excipients can be considered for the enteric coating of the particles. In addition to the better and faster solubility of the drug many important advantages can be realized with the selection of a proper excipient. Manufactured particles are resistant to low pH which results in delivery of particles to the intestinal tract without previously releasing the active ingredient. Depending on the choice of the polymer the drug will than be released at different parts of the intestines depending on the local pH value. Above all there the biological molecules such as peptides and proteins are here to call, for which until now the administration by intravenous infusion is the standard method.

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